[C-11]PiB PET Imaging in Alcohol Use Disorders

• Status: Completed
• Trial end date: 2020-07-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine whether alcoholics (AUD) have a greater rate of amyloid positivity (ABeta+) compared to an age-matched cognitively normal control group (HC).

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Pittsburgh
• Collaborator: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
• Treatments: Corticosterone

Criteria

[A] Alcohol Use Disorder Subjects (AUD)

Inclusion Criteria:

1. Males or females between 40 and 65 years old

2. Fulfill DSM-5 criteria for alcohol use disorder of at least moderate severity

3. Current heavy drinking as defined in SAMHSA criteria (i.e., drinking 5 or more drinks on the same occasion on each of 5 or more days in the past 30 days)

Exclusion Criteria:

1. DSM-5 schizophrenia, schizoaffective disorder, bipolar disorder (SCID-5) and prior history of developmental disorders, such as Autism, Down's Syndrome, Intellectual disability.

2. A positive urine drug screen at screening for amphetamines, cocaine, methamphetamine, opioids, barbituates and PCP

3. History of severe unstable medical or neurological illnesses that could affect neuropsychological testing

4. History of cancer (other than skin or in situ prostate cancer) within the previous 5 years

5. Currently pregnant or breastfeeding

6. Currently employed as radiation worker; or participation in radioactive drug research protocols within the previous year

7. Metal implants or paramagnetic objects contained within the body which may interfere with the MRI scan

8. No first-degree relative with Alzheimer's disease or related dementias

(B) Healthy Control Subjects (HC)

Inclusion Criteria:

(1) Males or females between 40 and 65 years old

Exclusion criteria:

1. Current or past DSM-5 psychiatric and/or addictive disorders

2. Current heavy drinking as defined in SAMHSA criteria

3. History of severe unstable medical or neurological illnesses that could affect neuropsychological testing

4. History of cancer (other than skin or in situ prostate cancer) within the previous 5 years

5. Currently pregnant or breastfeeding

6. Currently employed as radiation worker; or participation in radioactive drug research protocols within the previous year

7. Metal implants or paramagnetic objects contained within the body which may interfere with the MRI scan

8. No first-degree relative with Alzheimer's disease or related dementias